By Bertram G. Katzung, Anthony J. Trevor

Perfect for USMLE guidance and path evaluate, the streamlined, easy-to-follow hierarchical define structure courses scholars in the course of the most vital elements of every self-discipline. broad illustrations increase the texts and produce difficult-to-understand suggestions. medical correlations, a variety of tables and charts, and USMLE-style questions in medical vignette structure aid scholars review their strengths and weaknesses.

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Busulfan C. Cisplatin D. Methotrexate E. Vincristine A 35-year-old male sufferer present process chemotherapy for testicular melanoma has muscle weak point happen by way of trouble in status up from a sitting place. He additionally has constipation. four. If his difficulties are drug similar which of the next anticancer medications is probably to be dependable? A. Bleomycin B. Flutamide C. Leuprolide D. Paclitaxel E. Vincristine A sufferer with rheumatoid arthritis develops tuberculosis quickly after he starts off utilizing a brand new drug that in particular acts by means of interfering with tumor necrosis issue. five. This sufferer is being taken care of with which of the next? A. Aldesleukin B. Infliximab C. Leflunomide D. Mycophenolate mofetil E. Trastuzumab ahead of bone marrow transplantation a sufferer is handled with antilymphocytic globulin (ALG). He develops erythematous dermis eruptions, fever, lymphadenopathy, and arthralgia, that seem to be as a result of a drug response. 6. Which of the subsequent statements approximately this example is actual? A. Corticosteroids will accentuate those indicators B. Epinephrine will be administered instantly C. Antilymphocytic globulin often motives kind II autoimmune reactions D. The sufferer is being affected by serum disorder E. this can be a variety IV drug hypersensitivity 7. Which of the subsequent brokers is valuable in fighting rejection in organ transplantation and is way much less poisonous than immunosuppressive antibiotics or glucocorticoids? A. Azathioprine B. Cyclophosphamide C. Mycophenolate mofetil D. Rituximab E. Tacrolimus Drug-induced lupus differs from systemic lupus erythematosus (SLE) via its loss of gender bias, through its rare presentation of serious renal and neurologic signs, and through the reversal of signs on drug withdrawal. eight. Drug-induced lupus has been certainly linked to using which of the next? A. Hydralazine B. Methyldopa C. Procainamide D. Quinidine E. all the above * * * solutions 1. the answer's D. Mesna (mercaptoethanesulfonate) types a posh with acrolein, the metabolite of cyclophosphamide that motives bladder toxicity. Aldesleukin is a recombinant kind of interleukin-2; dexrazoxane blocks the formation of unfastened radicals which are accountable for the cardiotoxicity of doxorubicin; folinic acid is used to opposite methotrexate toxicity; nutrition B6 protects opposed to the peripheral neurotoxicity of isoniazid. 2. the answer's B. Fluorouracil (5-FU) is biotransformed to 5-fluorodeoxyuridine monophosphate (5-FdUMP), which inhibits thymidylate synthase and reasons a “thymine-less dying” of tumor cells. One mechanism of resistance to 5-FU comprises adjustments within the gene that encodes thymidylate synthase, top both to a rise within the synthesis of the enzyme or a reduce in its sensitivity to inhibition by means of 5-FdUMP. three. the answer's A. Pulmonary disorder happens with only a few anticancer medicinal drugs. Bleomycin is the anticancer drug most ordinarily linked to inflicting pulmonary fibrosis. Dermatotoxicity and pulmonary disorder also are identified hostile results of busulfan.

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